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Mechanisms underlying DNA replication and cell cycle control in Plasmodium

Project

Mechanisms underlying DNA replication and cell cycle control in Plasmodium

Project Details

My group studies the human malaria parasite Plasmodium falciparum.  Collaborative PhD projects can be offered in research areas centered around Plasmodium DNA biology: we are particularly interested in the molecular mechanisms underlying DNA replication and cell cycle control in Plasmodium, which replicates by an unusual method called schizogony.  We are also interested in mechanisms for silencing and promoting the recombination of a family of key virulence genes called var genes - particularly the role that G-quadruplex DNA structures may play in var gene control.  In fact, we have recently discovered that G-quadruplexes and their helicases have more general roles in genome stability and evolution in the malaria parasite as well.

Category
Microbiology and Infectious Disease
University
8
Project Listed Date
UK Mentor

Prof. Catherine Merrick

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