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Mitochondrial regulations and their roles in metabolic adaptation in hibernation

Project

Mitochondrial regulations and their roles in metabolic adaptation in hibernation

Project Details

Hibernation confers extraordinary protection against various forms of stress and insults that would be life-threatening to non-hibernators. However, the mechanisms of such promising protection remain elusive, hindering potential therapeutic applications. One of the hallmarks of hibernation is metabolic regulation, exemplified by modifications in mitochondrial respiration throughout the different stages of hibernation. Nonetheless, the possible link between metabolic regulation and cellular protection is unclear.  This project aims to study the mitochondrial regulations and their roles in metabolic adaptation during hibernation, in the context of neuroprotection.

Category
Cell Biology
Institute or Center
National Eye Institute (NEI)
University
8
Project Listed Date
NIH Mentor

Dr. Wei Li

UK Mentor

Prof. Mike Murphy

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