Category,Project,Project_Listed_Date,Institute_Center,NIH_Mentor,UK_Mentor,University,Project_Details "Health Disparities","Understanding Racial Differences In Heart Failure And Outcomes",2022-10,"National Heart, Lung, and Blood Institute (NHLBI)","Dr. Veronique Roger","Prof. Jonathan Weir-McCall",Cambridge,"Despite recent improvements in population health and prevention, heart failure prevalence and mortality are stagnant overall, with a disproportionate burden in Black, Hispanic and South Asian populations. Single centre studies provide highly phenotyped populations covering genomics, metabolomics, advanced imaging and longitudinal health trends. In contrast large centralized healthcare data covers decades of hospital admissions and mortality for millions of people, with this data growing in depth, richness and complexity. Collaborations that leverage both approaches have the unique potential of providing needed new insights in the poorly understood heart failure syndrome. Using advanced cardiac magnetic resonance imaging capabilities and novel biomarkers (NIH), we will conduct deep phenotyping in a diverse cohort of patients with heart failure to elucidate disease phenotypes and differences between races. At a national level (University of Cambridge) we will look at equitability of access to advanced imaging (such as MRI) and interventions (implantable defibrillators) and the impact of these on health outcomes."